Journal article
Ndfip1 mediates peripheral tolerance to self and exogenous antigen by inducing cell cycle exit in responding CD4 T cells
JA Altin, SR Daley, J Howitt, HJ Rickards, AK Batkin, K Horikawa, SJ Prasad, KA Nelms, S Kumar, LC Wu, SS Tan, MC Cook, CC Goodnow
Proceedings of the National Academy of Sciences of the United States of America | Published : 2014
Abstract
Contributed by Christopher C. Goodnow, December 17, 2013 (sent for review October 13, 2013) The NDFIP1 (neural precursor cell expressed, developmentally downregulated protein 4 family-interacting protein 1) adapter for the ubiquitin ligase ITCH is genetically linked to human allergic and autoimmune disease, but the cellular mechanism by which these proteins enable foreign and self-antigens to be tolerated is unresolved. Here, we use two unique mouse strains-an Ndfip1-YFP reporter and an Ndfip1-deficient strain-to show that Ndfip1 is progressively induced during T-cell differentiation and activation in vivo and that its deficiency causes a cell-autonomous, Forkhead box P3-independent failure ..
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Awarded by National Institute of Allergy and Infectious Diseases
Funding Acknowledgements
We thank the Genotyping Team of the Australian Phenomics Facility (APF) for expert mapping, sequencing, and genotyping; the staff of the APF for husbandry; Debbie Howard for expert technical assistance; and Dr. Ian Parish for advice on the manuscript. This work was supported by National Institutes of Health Grants AI100627 and AI054523, Wellcome Trust Grant 082030/B/07/Z, and National Health and Medical Research Council Grants 585490, 1016953, 427620, 1009190, and 1002863.